NICCRAT (Nottingham-Indonesia Collaboration for Clinical Research and Training) has secured funding from Newton Fund to support colorectal cancer research in Indonesia.

 

Newton Fund:

Improving Clinical Outcome in Indonesia with a Novel diagnostic test for 

Colorectal Cancer (ICONICC)

 

Principal Investigator (UK):

Professor Mohammad Ilyas (School of Medicine, University of Nottingham)

Partner Country:

Indonesia 

Partner Country Lead Investigator:

Dr. Susanna Hilda Hutajulu (Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada)

Associated Partners: Indonesia Institute of Science (Lembaga Ilmu Pengatahuan Indonesia/ LIPI), Indonesia Cancer Foundation (Yayasan Kanker Indonesia/ YKI) and Stem Cell and Cancer Institute of Kalbe Farma.

Total Grant:

£113,189

 Project Summary:

35,000 cases of colorectal cancer (CRC) pa occur in Indonesia. Around 35% of CRC are in patients <50 yo (compared to 5% in UK). They have poor outcome and many cases will be inherited. Management of CRC is by surgery but around 90% will also require chemotherapy. Standard therapy is 5FU but if they have a feature called deficient Mismatch Repair (dMMR), they will not respond and may do worse. They may respond to alternatives e.g. Irinotecan. There is a need to identify (i) cases which are dMMR to prevent ineffective therapy and (ii) patients with inherited cancer to improve lives by early treatment. This project addresses BOTH of these. Success will reduce the economic burden on the Indonesian health care system and remove the effects of loss of productivity. In this project, we will (a) Implement a new molecular test to detect both dMMR and inherited form of CRC (b) Perform a sophisticated analysis of CRCs: an in-depth analysis of CRC in young patients to explore disease biology, (c) Develop UK-Indonesia training schools and Focus Group Discussion (FGD) to promote knowledge exchange and adoption of new molecular test into clinical practice. The expected impacts of this project include the commercialization and implementation of the new molecular test which will lead to the prevention of approximately 5000 cases per year of over treatment and ineffective chemotherapy and detecting about 2450 inherited cases of CRC per year to allow the prophylactic therapy and surveillance of family members for early detection. In addition, the project will also contribute to the upskilling of Indonesia health care and research staff in the field of molecular diagnostics generate new data for the scientific community and new areas of research, particularly with regard to the high incidence of young patient with CRC in the country. 

Acknowledgement

This work was supported by a [Institutional Links] grant, ID [527558574], under the [Newton Institutional Link-Indonesia KLN Fund] partnership. The grant is funded by the UK Department for Business, Energy and Industrial Strategy and [Indonesia Ministry of Research Technology & Higher Education] and delivered by the British Council.

For further information, please visit www.newtonfund.ac.uk

ICONICC Team

  • Molecular Pathology Group, School of Medicine, University of Nottingham, UK
    Professor Mohammad Ilyas
  • Dr. Abhik Mukherjee
  • Ms. Susanti Susanti

Divisi Hematologi Onkologi Medik RSUP Dr Sardjito Yogyakarta

  • Susanna Hilda Hutajulu, Ph.D, Sp.PD-KHOM
  • Johan Kurnianda, Sp.PD-KHOM
  • Ibnu Purwanto, Sp.PD-KHOM
  • Kartika Widayati Taroeno-Hariadi, Sp.PD-KHOM
  • Mardiah Suci Hardianti, Ph.D, Sp.PD-KHOM
  • Meita Ucche, Sp.PD

Departemen Patologi Anatomi RSUP Dr Sardjito Yogyakarta

  • Didik Setyo Heriyanto, Sp.PA, Ph.D
  • Nungki Anggorowati, Sp.PA, Ph.D
  • Naomi Yoshuantari, Sp.PA

Divisi Bedah Digesti RSUP Dr Sardjito Yogyakarta

  • Dr. dr. Adeodatus Yuda Handaya, Sp.B-KBD

Departemen Histologi dan Biologi Sel FKKMK UGM

  • Dewi Kartikawati Paramita, S.Si, M.Si, Ph.D 

Pusat Studi Bioteknologi, Lembaga Ilmu Pengetahuan Indonesia

  • Dr. Wien Kusharyoto
  • Mr. Asep Ridwanuloh

Yayasan Kanker Indonesia

  • Prof. Dr. Aru W sudoyo, Sp.PD-KHOM

Pathgen Diagnostik Teknologi

  • Dr. Ahmad Utomo
  • Satrio Wibowo
  • Gilang Akbariani